Pharmacokinetics and Pharmacodynamics
This Course reviews pharmacokinetic concepts related to how medicines act on the human body, as well as pharmacokinetic concepts that explore how the human body acts on medicines.
UseUse your understanding of the relationship between pharmacokinetics and pharmacodynamics to prevent adverse medication events that may impact on patient outcomes
IdentifyIdentify the processes through which the human body absorbs, distributes, metabolises and eliminates medicines in order to educate patients on effective medication management
LinkLink the concepts of pharmacodynamics and pharmacokinetics with best clinical practice in order to enhance delivery of care
Associate Professor Louis Roller has been an academic at the Faculty of Pharmacy and Pharmaceutical Sciences Monash University for over 50 years. He was on the Pharmacy Board of Victoria for 22 years and has significantly contributed to many editions of various pharmaceutical compendia, including the Therapeutic Guidelines, particularly the Antibiotic Guidelines. He is the author of hundreds of scientific and professional articles and has a passion for evidence-based knowledge. He lectures to pharmacists, medical practitioners, nurses, podiatrists, and optometrists on a variety of therapeutic topics, particularly antibiotics, as well as giving many talks to the University of the Third Age on various medication-related issues. As at the end of April, he had delivered 42 talks to U3A Stonnington and an equivalent number to other U3A groups. With Dr Jenny Gowan, over the last 20 years, he has written articles on disease state management in the Australian Journal of Pharmacy. In 2012, he was made a life member of the Australasian Pharmaceutical Sciences Association and, in 2014, he was awarded the life-long achievement award of the Pharmaceutical Society of Australia.
- An overview of pharmacokinetics (PK) and pharmacodynamics (PD)
- The ADE (absorption, distribution and excretion) curve and the implications of the therapeutic range
- A definition of bioavailability and its effects on medicine quality, brand substitution and the use of generic medications
- How therapeutic medicine monitoring is used, how protein binding influences distribution, and how hepatic metabolic elimination and reabsorption occur
- Methods of medicine elimination, including renal elimination, and factors that affect elimination and reabsorption
- Multiple dose regimes, making reference to the definitions of peak and trough levels, loading dose and steady state
- Pharmacogenomics (personalised medicine) and genetic variability in response to medicines
- Pharmacokinetic medicine-medicine interactions
All healthcare professionals, particularly RNs, medication-endorsed ENs and Nurse Practitioners working in a variety of specialities.
Review the basic concepts relating to how medicines work on the human body, and the importance of bioavailability, half-life, medicine-medicine interactions, and peak and trough levels in therapy.
Pharmacological therapy and medication administration is fundamental in professional nursing practice. It involves a strong patient and ethical focus, as well as ongoing education in order to have a positive impact on patient outcomes. However, many of the principles underlying how medicines work are often difficult to comprehend. As safe administration of medicines is a priority, it is essential that nurses continue to demonstrate knowledge of the concepts and methods of medicine absorption, distribution and elimination in their patient care.
Health professionals in Australia that are registered with AHPRA are required to obtain continuing professional development (CPD) hours/points each year that relates to their context of practice, in order to comply with mandatory regulatory requirements.