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How Genetics Influences Medicine Metabolism

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Patient responses to medicines vary widely and the reasons for this are diverse and complex. It is estimated that genetic factors account for 20 to 95% of patient variability in response to individual drugs.

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Patient responses to medicines vary widely and the reasons for this are diverse and complex. It is estimated that genetic factors account for 20 to 95% of patient variability in response to individual drugs. Genetic influences on drug metabolism interact with other factors such as age, gender, race/ethnicity, disease states, concomitant medicines and social factors, determining the outcome from treatment with any pharmacological agent. There is some confusion as to which term to use - 'pharmacogenetics' or 'pharmacogenomics?'

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Louis Roller
Honorary Associate Professor
Dr Louis Roller has been an academic at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University for over 55 years. He served on the Pharmacy Board of Victoria for 22 years and is the author of hundreds of scientific and professional articles. Louis was made a life member of the Australasian Pharmaceutical Sciences Association in 2012 and was awarded the life-long achievement award from the Pharmaceutical Society of Australia in 2014. He is a prolific provider of education for Ausmed and for the University of the Third Age
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